He became a postdoctoral fellow in He also consulted for Bandler Corporation. Inhe joined SUSTech as an assistant professor. Cheng was one of the original contributors of Space Mapping algorithm. He has years of research experience in space mapping, simulator-based tuning, surrogate modeling, computer-aided design, modeling of microwave circuits, software design technology and methodologies for microwave CAD.

He has publications in refereed journals, conference papers, book chapters, etc. His publications have been cited near times as of April according to Google Scholar. Qingsha Shasha Cheng, Ph. Qingsha Shasha Cheng was born in Chongqing, China. He received his B. He received his Ph. Dash, Q. Cheng, and R. Accepted Z. Zhang, Q. Cheng, H. Chen, and F. Early Access J. Lv, H. Chen, Y. Zhang, Y.Thank you for visiting nature.

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In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. A Nature Research Journal. Endometriosis is a common, complex gynecologic disorder characterized by the presence of endometrial-like tissues at extrauterine sites. Elevation in protein and lipid mediators of inflammation including oxylipins and cytokines within the peritoneum characterize the inflamed pelvic region and may contribute to the survival and growth of displaced endometrial tissues.

The presence of a clinically silent but molecularly detectable systemic inflammation in endometriosis has been proposed. Thus, we examined serum oxylipin and immunomodulatory protein levels in women undergoing laparoscopy to evaluate systematically any involvement in systemic pathophysiological inflammation in endometriosis. Oxylipin levels were similar between women with and without endometriosis. Stratification by menstrual phase or severity did not offer any difference.

Serum oxylipin levels were not associated with pre-operative pain symptoms. Verification using C-reactive protein as a non-specific marker of inflammation further showed similar levels between groups. The implications of our work suggest pro-inflammatory mediators in the classes studied may have potentially limited value as circulating biomarkers for endometriosis, suggesting of potentially tenuous systemic inflammation in endometriosis.

Pain and infertility are two prominent symptoms most commonly associated with the endometriosis and have been attributed to chronic inflammatory state of the pelvic peritoneal area with altered immunological and inflammatory milieu in the microenvironment 1. This can be deduced by two main features found in the peritoneal environment—i the increase in immune cells and ii the elevation of pro-inflammatory immunomodulatory proteins cytokines and chemokines and lipid mediators such as prostaglandins in the peritoneum and peritoneal fluids of women with endometriosis 234567.

This has led to the questioning of whether endometriosis is accompanied by a clinically silent systemic inflammation 10 and resulted in searches for circulating inflammatory markers which could potentially predict endometriosis. Inflammation is biochemically modulated by oxylipins cooperating with cytokines and chemokines Oxylipins are known to exhibit paracrine, autocrine and increasingly endocrine effects, acting on both local and distant targets by secretion into the circulation Considering the pivotal physiological and pathophysiological roles of oxylipins and immunomodulatory proteins in inflammation, we used them as assessors of systemic inflammation in endometriosis.

We report limited systemic inflammation in women with endometriosis and the results was corroborated with the non-specific inflammation marker, C-reactive protein Our extensive profiling here from well-defined cases and controls suggests that systemic pro-inflammatory mediators are likely to have limited diagnostic value in endometriosis.

Our results inform prospective researchers in the search for biomarker discovery of endometriosis diagnosis to refrain from pro-inflammatory mediators in the circulation. Exclusion criteria include patients who are menstruating, anovulatory, post-menopausal, on hormonal therapy for at least three months before laparoscopy or anti-inflammatory medication a day before laparoscopy and other potentially confounding diseases such as diabetes, adenomyosis or any other chronic inflammatory diseases rheumatoid arthritis, inflammatory bowel disease, systemic sclerosis, etc.

The following patients were excluded: seven menstruating patients, two with undeterminable menstrual phase, two with irregular menstrual phase, two anovulatory patients and one patient with undetermined endometriosis severity scoring.

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Women provided written informed consent for collection of samples and were carried out in accordance with stipulated guidelines and regulations under Centralised Institutional Research Board approval CIRB D.A prerequisite for successful embryo implantation is adequate preparation of receptive endometrium and the establishment and maintenance of a viable embryo.

The success of implantation further relies upon a two-way dialogue between the embryo and uterus. However, molecular bases of these preimplantation and implantation processes in humans are not well known.

We integrated these data with protein-protein interactions in order to identify molecular networks within the endometrium and the embryo, and potential embryo-endometrium interactions at the time of implantation.

For that, we applied a novel network profiling algorithm HyperModules, which combines topological module identification and functional enrichment analysis. We found a major wave of transcriptional down-regulation in preimplantation embryos. In receptive-stage endometrium, several genes and signaling pathways were identified, including JAK-STAT signaling and inflammatory pathways.

The main curated embryo-endometrium interaction network highlighted the importance of cell adhesion molecules in the implantation process. We also identified cytokine-cytokine receptor interactions involved in implantation, where osteopontin SPP1leukemia inhibitory factor LIF and leptin LEP pathways were intertwining. Our findings provide a fundamental resource for better understanding of the genetic network that leads to successful embryo implantation. We demonstrate the first systems biology approach into the complex molecular network of the implantation process in humans.

Successful embryo implantation is an absolute requirement for the reproduction of mammalian species. In humans, implantation involves complex interactions between the embryo and the maternal endometrium, all of which must be performed within an optimal time frame.

Critical to successful implantation is the embryo's development into an implantation-competent blastocyst and the synchronized transformation of the uterus into a receptive stage 1. During this window, ovarian estrogen and progesterone induce the endometrial cells to proliferate, differentiate, and secrete molecules that influence trophoblast development.

Meanwhile, the presence of an embryo in the uterus triggers specific molecular and cellular responses within the endometrium 4. The success of embryonic implantation further relies upon a two-way dialogue between the blastocyst and the endometrium, which involves cell-cell and cell-extracellular matrix ECM interactions, mediated by integrins, matrix-degrading enzymes and their inhibitors, a variety of growth factors and cytokines, and their receptors and modulator proteins 5. Indeed, in assisted reproductive techniques, where often high-quality embryos are transferred, implantation remains the rate-limiting step for the success of treatment 89.

Therefore, a better understanding of the implantation process, and the importance of the factors involved, is warranted. Many studies have been performed to improve understanding of the molecular mechanisms involved in embryo-maternal cross talk. However, most of the information regarding what is believed to occur during human implantation is derived from animal models, largely from studies on mice 10— 12because it is ethically and practically extremely difficult to study human implantation processes in vivo Animal models do provide important clues to the processes regulating human implantation, but because the process varies across species 4the results cannot always be extrapolated to humans.

With the development of microarray technology, numerous whole-genome expression analyses of the human endometrium have revealed hundreds of simultaneously up- and down-regulated genes that play a role in endometrial receptivity 14— Information concerning the molecular basis of human preimplantation development is limited, and only a few studies have been reported 25— In this study, we performed a comprehensive computational analysis of the molecular interaction network underlying the embryo-endometrium interface during implantation.

Using a systems biology approach, we integrated embryonic and endometrial transcriptomic profiles with protein-protein interactions. Our analysis revealed a collection of proteins, functional protein modules, and pathways that are activated within the preimplanting blastocyst and in the receptive endometrium.

Furthermore, we characterized a high-confidence network of cross-tissue protein interactions that outline the molecular nature of the embryo-endometrium implantation interface.

Embryo implantation occurs between blastocyst-stage embryo d 5 after conception and the endometrium in its receptive stage midsecretory phase endometrium. To identify the transcriptional profile within the blastocyst and the receptive endometrium, we used microarrays to profile d-3 vs.

Transcriptional profiling of the embryo-endometrium interface. B, Functional scores of known genes in embryonic and endometrial gene lists from GO and pathway enrichment analysis.

We then applied the incremental enrichment analysis algorithm from the g:Profiler tool 31 to study the functions of the genes involved. This algorithm extends gene set enrichment analysis by assessing the functional significance of increasingly larger sets of genes with the most dramatic transcriptional changes.

In contrast to fixed gene set analysis, incremental enrichment analysis detects both specific functions and pathways that exhibit strong transcriptional signals, as well as broader categories that are widely represented within differentially expressed genes. In addition, we combined the above analysis with KEGGanim software, which highlights genes in pathway maps according to their differential expression In our previously published study, where we applied different array data analysis tools, these preimplantation embryos also demonstrated a significant number of down-regulated genes involved in transcription regulation Transcriptional and RNA metabolic machinery is known to be active during the embryonic genome activation that takes place before blastocyst formation Buy Polyethylene - U.

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A modest range of fibre, braided cord and fabrics are available from Goodfellow. Like Kevlar, these fibres have very high tensile properties and small negative CTE's. Their energy absorption and acoustic velocity characteristics are superior to Kevlar's both as fabric and composite. Applications are being developed particularly in the areas of ballistic protection and ropes in the widest sense. Skip navigation Accessibility information.

Your global supplier for materials Product Search. Polyethylene - U. See also General Information under Polyethylene - Low Density General Description : A semi-crystalline, whitish and effectively opaque engineering thermoplastic which, chemically, is a very high molecular weight million HDPE.

Coefficient of thermal expansion x10 - 6 K - 1. Thermal conductivity 23C W m - 1 K - 1.See the full gallery. A military experiment to create a race of super-warriors go awry, and legions of murderous zombies are unleased upon a surburan neighborhood. A delicious, mysterious goo that oozes from the earth is marketed as the newest dessert sensation, but the tasty treat rots more than teeth when zombie-like snackers who only want to consume more of the strange substance at any cost begin infesting the world.

Meanwhile, something big is attacking people of New York and only greedy small time crook Jimmy Quinn knows where its lair is. A liquor store owner sells alcoholic beverages to homeless people, unaware of what the bottles actually contain: toxic brew.

A group of young shopping mall employees stay behind for a late night party in one of the stores. When the mall goes on lock-down before they can get out, the robot security system malfunctions, and goes on a killing spree.

A family's new satellite TV system starts receiving signals from another planet, and soon it becomes the passageway to an alien world.

Ten teenagers party at an abandoned funeral parlor on Halloween night. When an evil force awakens, demonic spirits keep them from leaving and turn their gathering into a living Hell. A young man carrying a big basket that contains his extremely deformed Siamese-twin brother seeks vengeance on the doctors who separated them against their will.

Angela Baker, a shy, traumatized young girl, is sent to summer camp with her cousin. Shortly after her arrival, anyone with sinister or less than honorable intentions gets their comeuppance. Alien brain parasites, entering humans through the mouth, turn their host into a killing zombie. Some teenagers start to fight against them. Doctors Herbert West and Dan Cain discover the secret to creating human life and proceed to create a perfect woman from dead tissue.

A rash of bizarre murders in New York City seems to point to a group of grotesquely deformed vagrants living in the sewers. A courageous policeman, a photo journalist and his girlfriend, and a nutty bum, who seems to know a lot about the creatures, band together to try and determine what the creatures are and how to stop them.

Soon he teams up with a photographer John Heard and a soup kitchen owner Daniel Stern and the trio try to uncover what is behind all the people disappearing. For me the film is a decent "B" picture but nothing more as there's really not anything too special here.

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Fans of the low-rent 80's horror movies will probably want to check it out but the film should've been much better than it actually is. The problem I have with the film is that so much of the action takes place off the screen.

We know what the monsters are doing yet we never really see any of it for the first hour as they are kept off screen with the viewer only getting a couple brief looks at their arms. This here was probably done because of the budget but there's just not enough attacks going on to keep you entertained. I'd also argue that there's no suspense or tension to be found anywhere and it certainly doesn't help that it's dragged out for minutes.

The cast is certainly a lot better than the actual material. Curry makes for a good lead and I thought he gave a good performance. The monsters, once we do finally see them, look pretty good but sadly their appearance happens way too late into the picture. Sign In. Keep track of everything you watch; tell your friends. Full Cast and Crew. Release Dates.

Official Sites. Company Credits. Technical Specs.Top definition. Chud is an insult frequently used, by leftiststo deride members of the Alt-right or other right wing groups. The word has been used as a sarcastic derision for decades, but has only attained the political slant fairly recently.


Antifa : Look at those Proud Boys over there. Other Antifa: What a bunch of fuckin' chuds. Jul 15 Word of the Day. Gender Euphoria. When they used my proper pronounsmy gender dysphoria became gender euphoria. But is now used to describe ugly stupid people.

Most notably in the Kevin Smith film Clerks 2 The phrase is mostly used in America but is now starting to become popular in the UK.

Jamie: Why don't girls like me? Scott: Because you're a fucking chud! Mother: Nurse when can i see my baby? Nurse: Are you sure you want to?


Mother: yes of course! Nurse: well because your baby is so fucking ugly. It must take after you. You chud. Canibalistic Humanoid Underground Dweller.

Defined in the movie of the same name. Acronym for " Cannibalistic Humanoid Underground Dweller " 2. The most dazzlingly significant piece of cinematic history. Used to describe someone who is repulsively unattractive.


Alternately, someone who is amateurish or unsuccessful in any given field. Originally from the horror film C. Further popularized by the Kevin Smith comedic film Clerks II in which the term was used as an intensifier to describe someone's unattractiveness e.

You ugly chud! There are some ugly chuds at this party! Way to fail that exam. You're such a chud.The plot concerns a New York City police officer and a homeless shelter manager who join forces to investigate a series of disappearances, and discover the missing are taken by humanoid monsters that live below the city. The title of the movie stands for C annibalistic H umanoid U nderground D wellers.

It was followed in by C. II: Bud the C. The film opens with a woman, Flora Bosch, walking her dog down an empty, darkened city street. As she passes by a manholea creature attacks Mrs.

Bosch and drags her and the dog into the sewers. George Cooper, a once-prominent fashion photographer, has since forgone fame and fortune and is living with his girlfriend Lauren.

His current project is photographing New York City's homeless population, specifically those known as "undergrounders", or people who reside within the bowels of the city. NYPD Captain Bosch has a personal interest in the recent flood of missing persons being reported to his precinct, as Flora, his wife, remains missing.

Bosch interviews A. Bosch's superiors know more than they are letting on and seem to be taking their cues from Wilson, who works for the Nuclear Regulatory Commission NRC. It turns out that monsters are lurking beneath the streets; beings that were once human, but have been mutated by radioactive, chemical toxic waste into hideous, flesh-eating creatures that prey on the homeless who live in the underground.

Given the recent drop in the underground transient population, the creatures have resorted to coming to the surface through sewer manholes to feed. Through a series of events, both George and A. Although the political bureaucracy has forbidden the NRC to transport the toxic wastes through New York because of the large-scale danger to the public, it has secretly been hiding the waste by-products, marked as "Contamination Hazard Urban Disposal", beneath Manhattan in the abandoned subway tunnels.

The underground homeless population has been coming into contact with these by-products, turning them into the mutated creatures. To protect this secret, Wilson plans to seal the sewers, open up some gas lines and asphyxiate the C. In the meantime, Lauren is attacked by the mutants in her apartment and narrowly escapes them.

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Later that evening at a diner, two police officers and the waitress are killed and carried off by the mutants, finally drawing the public's attention to the disappearances. George and A. Confronted by Bosch, Wilson runs off, and later shoots Bosch while the latter helps A. Wilson then tries to run George and A. The company released the film again in as a part of its Cult Fiction series. It is meant to be light commercial entertainment, and in the category of horror films it stands as a praiseworthy effort".

Club wrote, "Perfect for bleary-eyed late-night viewing and pretty much unwatchable at any other hour. A sequel, C. D appears in the video game Tony Hawk's Underground under the name T. The upcoming found footage horror film Dwellers has been publicly referenced by its writer and director Drew Fortier as being heavily influenced by C.

From Wikipedia, the free encyclopedia. For other uses, see CHUD disambiguation. This article has multiple issues. Please help improve it or discuss these issues on the talk page. Learn how and when to remove these template messages. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.

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